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Didier M. Lambert (Ed.)

Cannabinoids in Nature and Medicine






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ISBN-10: 3-906390-56-X
ISBN-13: 978-3-906390-56-7
416 pages
August 2009


Originally a special issue of Chemistry & Biodiversity, the first part of this volume focuses on the plant Cannabis sativa, its active ingredients, therapeutic applications, toxicology and cannabis prohibition, while the second part covers the journey from humans to plants.


Cannabis and Endocannabinoids: "The Old Man and the Teenagers" (D. M. Lambert)

PART 1. The Phytocannabinoids: The Long Journey from the Plant to the Humans

History of Cannabis and Its Preparations in Saga, Science, and Sobriquet (E. B. Russo)

Phytocannabinoids in Cannabis sativa: Recent Studies on Biosynthetic Enzymes (F. Taura, S. Sirikantaramas, Y. Shoyama, Y. Shoyama, S. Morimoto)

On the Pharmacological Properties of delta9-Tetrahydrocannabinol (THC) (B. Costa)

Cannabidiol - Recent Advances (R. Mechoulam, M. Peters, E. Murillo-Rodriguez, L. O. Hanus)

From Active Ingredients to the Discovery of the Targets: The Cannabinoid Receptors (K. Mackie)

Medicinal Chemistry Endeavors around the Phytocannabinoids (E. Stern, D. M. Lambert)

Cannabis, Pain, and Sleep: Lessons from Therapeutic Clinical Trials of Sativex, a Cannabis-Based Medicine (E. B. Russo, G. W. Guy, P. J. Robson)

The Toxicology of Cannabis and Cannabis Prohibition (F. Grotenhermen)

Human Cannabinoid Pharmacokinetics (M. A. Huestis)

Blocking the Cannabinoid Receptors: Drug Candidates and Therapeutic Promises (G. G. Muccioli)

PART 2. The Endocannabinoid System: The Short Journey from the Humans to the Plants

Discovery and Isolation of Anandamide and Other Endocannabinoids (L. O. Hanus)

Biosynthetic Pathways of the Endocannabinoid Anandamide (Y. Okamoto, J. Wang, J. Morishita, N. Ueda)

The Multiple Pathways of Endocannabinoid Metabolism: A Zoom Out (S. Vandevoorde, D. M. Lambert)

Fatty Acid Amide Hydrolase: From Characterization to Therapeutics (G. Labar, C. Michaux)

Monoglyceride Lipase as an Enzyme Hydrolyzing 2-Arachidonoylglycerol (S. M. Saario, J. T. Laitinen)

The N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) (K. Tsuboi, N. Takezaki, N. Ueda)

Genetic Polymorphisms of the Endocannabinoid System (A. G. Norrod, R. A. Puffenbarger)

The N-Acylethanolamine-Mediated Regulatory Pathway in Plants (A. Kilaru, E. B. Blancaflor, B. J. Venables, S. Tripathy, K. S. Mysore, K. D. Chapman)